Manchester City's unforeseen and catastrophic downturn in form has been one of the major storylines of the season so far, with their latest defeat arriving in the Champions League as their hopes of reaching the knockout stages took a major blow at Juventus.
Their opponents managed to shake off two defeats in a row by downing Viktoria Plzen in the Europa League, but their standing in England's top flight is in need of improvement as Ruben Amorim plots a charge up the table.
Here's everything you need to know about Sunday's huge Manchester derby.
Man City team news
Lewis scored and was sent off against Palace
City's strong core of defenders is depleted right now, with John Stones and Nathan Ake unavailable for Sunday's derby and Manuel Akanji unlikely to recover in time. Those absences could see 19-year-old Jahmai Simpson-Pusey start a third game this season.
Adding to Pep Guardiola's woes is the suspension picked up by Rico Lewis, who was sent off for two bookable offences in the 2-2 draw with Crystal Palace last week.
Rodri and Oscar Bobb remain on the sidelines with long-term issues.
Man Utd team news
Shaw is United's only current injury absentee
United have a relatively clean bill of health as they attempt to earn a first league win at the Etihad since 2021.
The Red Devils came through Thursday's Europa League win over Viktoria Plzen with no new injury concerns and Jonny Evans could return to the matchday squad to provide head coach Amorim with another option.
Luke Shaw is the only player definitely ruled out as he recovers from his latest fitness setback.
Man City vs Man Utd score prediction
Man City have enjoyed this fixture in recent years but there will be a very different vibe on Sunday, with a huge victory not automatically expected as usual.
The reigning English champions are finding consistency hard to come by and their injuries in the crucial centre-back position will be music to the ears of United's squad.
Amorim has secured a big win against Guardiola already this season when Sporting CP thrashed City in the Champions League. His formation will likely cause an out-of-sync City problems and the Red Devils should be able to secure a share of the spoils.
Prediction: Man City 2-2 Man Utd
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- 2 Mikel Arteta ready to give his life to deliver silverware for Arsenal
- 3 Chelsea beat Manchester United in FA Cup final to seal domestic treble
- 4 Mikel Arteta apologises for failing to deliver Arsenal a Premier League title
- 5 Liverpool cleared to complete signing
- 6 Marc Guehi to land transfer to Real or Barca
- 7 Real Madrid agree deal for Dean Huijsen
- 8 Dele Alli’s girlfriend Cindy sets pulses racing in barely
- 9 Man City withdraw and Liverpool could steal
- 10 3 EPL giants have advantage in Osimhen race