On Friday, Brazilian outlet Direto Do Miolo claimed on social media that Messi and Roccuzzo were facing the "biggest crisis" in their 15 years of marriage.
Cesc Fabregas' wife Daniella Semaan, right, has denied Lionel Messi, left, cheated on Antonela Roccuzzo, centre-left
A Brazilian outlet made the allegation about Messi committing infidelity
The publication alleged that Messi had an affair with Argentine journalist Sofia Martinez.
They also claimed the couple's marriage was on the brink.
But the post quoted sources from Spain that do not appear to exist.
And Daniella Semaan, wife of ex-Arsenal, Barcelona and Chelsea man Fabregas, has quashed the rumours.
She said: "What publication is this that has no meaning.. and has nothing right."
Fabregas and Semaan regularly holiday with Messi and Roccuzzo.
Messi and Fabregas played together as youngsters at Barcelona's La Masia academy.
They then featured alongside each other for three years in Barcelona's first team when Fabregas joined from Arsenal in 2011.
The allegation was made that Messi cheat on his wife with journalist Sofia Martinez
Fabregas, left, and Daniella, right, are good friends. of Messi and Roccuzzo
Messi and Roccuzzo, who have known each other since they were five years old, have three children together - Thiago, 11, Mateo, 8, and Ciro, 5.
Journalist Martinez made headlines at the World Cup last year when she produced a passionate speech at the end of an interview with Messi following Argentina's semi-final triumph.
She said: "The last thing I want to tell you, and is not a question, but I just wanted to say; the World Cup final is coming and sure, we all [Argentinians] want to win the Cup.
"I just want to tell you that no matter the results, there's something that no one can take from you and that is the fact you resonated with Argentinians, every single one. I'm being serious.
"There's no kid who doesn't have your team shirt. No matter if it is a fake, real or made up one.
"Truly, you made your mark in everyone's life and that to me is beyond winning any World Cup.
"No one can take that from you and this is my gratitude for such amount of happiness you bring to a lot of people.
"I seriously hope you take these words into your heart because I really believe that's more important than winning a World Cup and you already have it, so thank you captain."
Messi and Roccuzzo have known each other since they were kids
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